Synthesized the evidence and wrote the initial draft: Wang, T
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Blood 63:96104 Calabrese V, Cornelius C, Rizzarelli E, Owen JB, Dinkova-Kostova AT, Butterfield DA (2009) Nitric oxide in cell survival: a Janus molecule
Lipid metabolism Lipidomic studies have shown that phosphatidylethanolamines (PEs) with arachidonic acid (AA) or its derivative adrenergic acid (AdA) are the key phospholipids for oxidation, and their peroxidation is considered a significant driver of ferroptosis [19, 21]
Reduces wrinkles and fine lines : Collagen smoothes the skin and prevents wrinkles
GPR146 deficiency reprograms hepatic glucose and amino acid metabolism Beyond reduced hepatic lipid accumulation, GPR146 deficiency led to significantly elevated levels of hexose metabolites within the pentose phosphate pathway (PPP), including hexose monophosphate and erythrose-4-phosphate (Supplementary Fig